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No. 15 · Hormones
Perimenopause Care
Symptoms, answers, options
Perimenopause is the transition before menopause, when hormones swing and periods change, and it most often begins between ages 45 and 55. Symptoms like night sweats, sleep trouble, mood changes, weight changes and brain fog are common, and a licensed provider can review them in an online visit and discuss hormone and non-hormone options.
For the transition before menopause.
| Option | Monthly | Quarterly, 3 months | Start |
|---|---|---|---|
| Estradiol tablets | $120 | $155about $52 a month | Start |
| Progesterone capsules | $140 | $210about $70 a month | Start |
| Estradiol patch | $195 | $375about $125 a month | Start |
Prices include the online visit, licensed provider review, medication and shipping. Quarterly plans ship three months at a time. Cancel or pause anytime. Available online in Detroit, Metro Detroit and across Michigan, and in other states where our providers are licensed.
Online visits for Detroit, Metro Detroit and Michigan. Questions first? Email support@hoolongevity.com or call (586) 321-3377.
Who it's for
- Women in their late 30s, 40s or early 50s with new cycle changes or symptoms
- Women who still have periods but feel different
- Women who were told to wait it out and want options
Not for
- Emergencies: call 911 for chest pain or stroke symptoms
- Anyone who needs an in-person exam first, which your provider will advise
Your licensed provider reviews your full history and decides what is appropriate.
How it works
Track your cycle and symptoms (our symptom checklist helps)
Complete the online visit
A licensed provider reviews your history and discusses options, including hormone therapy if appropriate
Medication ships from a licensed US pharmacy
What's included
- Online visit and licensed provider review
- Medication if prescribed, at the prices on the menopause page
- Shipping in discreet packaging
- Follow-up messaging
Important safety information
- Standard hormone therapy doses are not birth control, so some women in perimenopause still need contraception.
- Other conditions, such as thyroid problems, can cause similar symptoms, so your provider may suggest checking for them.
- If you have significant anxiety, panic or low mood, tell your provider. If you ever have thoughts of harming yourself, call or text 988.
Prescription only. A licensed provider reviews your health history in an online visit and decides whether this program is appropriate for you. Tell your provider about every medication, supplement, allergy and condition, and whether you are pregnant, trying to conceive or breastfeeding. If you have a severe reaction, trouble breathing, chest pain or swelling of the face or throat, call 911.
Full details: safety information. Updated November 3, 2026.
Questions, answered
Straight answers about Perimenopause Care.
What are the signs of perimenopause in your 40s, even if your periods are still regular?
Perimenopause can start while you still have periods, and common signs include cycle changes, hot flashes or night sweats, trouble sleeping, mood changes or anxiety, brain fog and vaginal dryness. The menopausal transition most often begins between ages 45 and 55, though some women notice changes earlier. If symptoms are affecting your life, an online visit with a licensed provider is a good place to start.
Can perimenopause start at 38 or 39?
Yes, some women notice perimenopause symptoms in their late 30s, though it more commonly begins in the mid to late 40s. Other conditions, such as thyroid problems, can cause similar symptoms, so a licensed provider may suggest checking for them. Menopause before 40 is considered early and is worth discussing with a provider.
Do I have to wait until the hot flashes start before I can try HRT?
No, hot flashes are not required; hormone therapy may be considered for other bothersome symptoms, such as night sweats, sleep disruption and vaginal dryness, depending on your health history. The Menopause Society states that for healthy women under 60 or within 10 years of menopause, the benefits of hormone therapy for symptoms generally outweigh the risks. A licensed provider will review your symptoms and history in the online visit.
Can I take HRT if I'm still getting my period?
Yes, many women in perimenopause use hormone therapy while still having periods, though the type and schedule may differ from postmenopausal regimens. Standard HRT doses are not birth control, so some women in perimenopause still need contraception. A licensed provider can recommend options based on your cycle and goals.
Can HRT help with perimenopause anxiety and mood swings?
Hormone therapy may ease mood symptoms that come with perimenopause for some women, especially alongside hot flashes and poor sleep, but it is not a stand-alone treatment for anxiety disorders or depression. If you have significant anxiety, panic or low mood, tell your licensed provider, and if you ever have thoughts of harming yourself, call or text 988 right away. Some women do best with HRT combined with other mental health care.
Are joint pain, itchy skin and heart palpitations really perimenopause symptoms?
Many women report joint aches, dry or itchy skin, palpitations and headaches during perimenopause, and changing hormone levels may play a role. These symptoms can also have other causes, so new palpitations or chest pain should be checked promptly, in person if severe. Describe all your symptoms in your online visit.
What's the difference between perimenopause and menopause?
Menopause is the point 12 months after your last period, and perimenopause is the transition before it, when hormones fluctuate and periods become irregular. The menopausal transition most often begins between ages 45 and 55 and can last several years. Symptoms can continue after menopause too.
Sources
- National Institute on Aging, What Is Menopause?
- The 2022 hormone therapy position statement of The North American Menopause Society, Menopause (2022)
- Avis et al., Duration of Menopausal Vasomotor Symptoms Over the Menopause Transition (SWAN), JAMA Intern Med (2015)
- UBC Centre for Menstrual Cycle and Ovulation Research, Can a blood test tell me whether I am in menopause?
- The 2023 nonhormone therapy position statement of The North American Menopause Society
Reviewed November 3, 2026.
Read more
Health GuideHow Do I Know If I'm in Perimenopause? A Symptom Checklist
Most women recognize perimenopause from a pattern of changes, such as shifting cycles, night sweats, poor sleep and mood changes, usually starting in their 40s. No single test confirms it, so tracking symptoms is the most useful first step.
Menopause and HormonesThe 2026 HRT Boxed Warning Change, Explained
In November 2025 the FDA began removing boxed warning language about heart disease, breast cancer and dementia from menopause hormone therapy labels, and approved the first six updated labels on February 12, 2026. The endometrial cancer warning stays on estrogen-alone products.
Menopause and HormonesAre Bioidentical Hormones Safer Than Synthetic Hormones?
Not necessarily. Bioidentical means chemically identical to your own hormones, and several FDA-approved products already are. There is no good evidence that compounded bioidentical hormones are safer or more effective than approved hormone therapy.
Ready to start?
A licensed provider reviews your online visit and decides whether Perimenopause Care is right for you.